Rudimental were presented with the best album award.
Tinie Tempah opened the ceremony with a rendition of Trampoline and later won best UK hip hop or grime act, the second time he has won that category.
Laura Mvula won two awards
The ceremony, which was hosted by BBC Radio 1Xtra’s Trevor Nelson and Sarah-Jane Crawford, featured live performances from Iggy Azalea and Aluna George.
The Mobos, the Music Of Black Origin awards, were launched in 1996 and were the first music awards event in Europe to focus on urban music.
A special award was also presented to the mother of murdered teenager Stephen Lawrence.
Baroness Doreen Lawrence was recognised for setting up a charitable trust in the name of her son who was killed in a racist attack in Eltham, south-east London in 1993.
The award recognises people and organisations who “represent the Mobo values for forward thinking.”
Mobo founder Kanya King praised the trust for its work to support young people from diverse and disadvantaged backgrounds.
Baroness Lawrence said: “We have helped over 100 students and we have now six of them who are qualified architects in this country and there are four out in Jamaica.”
Mobo 2013 winners
Best Female – Laura Mvula
Best R&B or soul artist – Laura Mvula
Best Male – Wiley
Best UK hip hop or grime act – Tinie Tempah
Best Song – Naughty Boy (La La La!)
Best Reggae Artist – Sean Paul
Best Newcomer – Krept and Konan